BCS 240 Lecture Notes - Lecture 26: Olfactory Receptor Neuron, Olfactory Receptor, Adenylyl Cyclase
11 Nov 2018
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10:21 am primary functions of olfaction: find/evaluate food prior to ingestion flavor perception avoid noxious/toxic aerosols predator-prey interactions (predators mark their territory) social behavior/communication in animals (i. e. territoriality, social aggression, mating via pheromones) 11-5 odor objects the things that we smell; complex mixtures of odorants odorants can be small/volatile molecules or large/complex molecules. Osns are replaced every 10-28 days via the differentiation of basal cells (axons need to be regrown/to find their targets each time) Osns use indirect transduction cilia of osns have a specific odorant receptor proteins that, when the right odorant is bound, a golfactory protein is released inside the cell. Golf functions like g s (activates adenylyl cyclase, which makes cyclic amp) camp directly opens na+/ca2+ ion channels, allowing both types of ions to enter the cell and depolarizing the cell. Ca2+ activates cl- channels, creating a substantially depolarizing outward cl- flow (inward current amplifies the signal)
