BIO 110 Lecture Notes - Lecture 24: Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase, Lipoic Acid
Document Summary
Occurs in mitochondrial matrix (space inside both of the membranes) Disadvantage: needs final product to begin cycle (can"t begin without completing) Advantage: traffic circle, intersection of many metabolic pathways. Used pigeon flight muscles - require lots of atp breaking down lots of carbohydrates (basically krebs cycle) Krebs cycle/ citric acid cycle/ tricarboxylic acid cycle. Acetyl-coa (2c) is added to oxaloacetate (4c) to make citrate (6c) With time, one molecule of oxaloacetate (and enzymes) can oxidize any number of acetyl groups. Major product is electrons - 4 pairs every cycle put on electron carriers electron transport chain. A problem - glycolysis ends with pyruvate (3c) but the. The solution - pyruvate dehydrogenase complex (pyruvate to acetyl-coa) Convenient handle for holding onto carbon compounds. The sulfur can easily form and break bonds with carbon. Contains multiple copies of 3 major enzymes and uses 5 cofactors. Overall reaction: takes pyruvate produces acetyl-coa and co2 (pulling electrons off for nad+)
