BIO 110 Lecture 25: BIO 110
Document Summary
Hub of metabolism - intersection for many pathways. Diabetes - the inability to do insulin signaling correctly. Insulin signaling - concerns blood glucose levels. Blood glucose too low needs more glucose from liver. Blood glucose too high insulin is released into the blood. Type 1 - don"t make insulin at all. Type 2 - stop responding to insulin signaling (more common) Diabetes mellitus - the body doesn"t know that it has plenty of glucose (even though it does) and thus: It thinks that is starving (even though it isn"t) Carbohydrates are pretty reactive react to proteins in non-enzymatic way (negatively affects structure of protein) Buildup of very high blood glucose levels (mental confusion) Excretion of large amounts of glucose in the urine. Diversion of tca cycle intermediates to gluconeogenesis (fatigue) Excessive but incomplete fatty acid oxidation (ketosis from ketone body buildup) Pancreas has glucose sensor releases insulin.
