BCS 242 Lecture Notes - Lecture 15: Differential Diagnosis, Micrographia, Nigrostriatal Pathway
10 Nov 2016
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Vascular dementia (vad): dementia caused by single/multiple strokes: causes: cvd, cardiovascular/circulatory disturbances, 2nd-3rd most common form of dementia 20% worldwide, higher prevalence in men, populations affected by cerebral small-vessel disease (asian, african american, hispanic, diagnosis. Determine cognitive loss decline from baseline. Must find temporal link between stroke/incident, cognitive loss. Dementia onsets within 3m of recognized stroke usually. Stepwise progression of disease abrupt deterioration: fluctuating cognitive function. Must exclude other possible causes: is preventable risk factors are modifiable, vascular cognitive impairment: cognitive loss short of dementia with. Cvd risk factors (eg. , hypertension, high cholesterol, etc. ) Patients can improve over time may never progress to vad: mixed dementia: have cognitive loss in at least 2 domains, but at autopsy find both ad pathology (plaques, tangles), evidence of cvd. Cvd may catalyze mci to dementia: helps with differential diagnosis of dementia. Early stages of dementia are different across types cognitive profiles are different. Primary sign: memory impairment decreased encoding, storage.
