BIOL 134 Lecture Notes - Lecture 28: Facultative Anaerobic Organism, Shigellosis, Enterobacteriaceae
Document Summary
Fluids secreted into the intestines; watery stool. Often in response to toxins in the gut. Diarrhea is often a symptom of dysentery. Often accompanied by blood and/or white blood cells in the stool. Due to production of exotoxin (shiga toxin) + invasive. Shiga toxin causes cell death and can damage the kidney. Movement from cell to cell without exposure to the immune system. A few patients develop long-term autoimmune disease. Due to bacterial remnants in the blood over-activating the immune system. All shigellosis is due to person to person infection. Long incubation food poisoning: 12 to 36 hours. Usually not treated with antibiotics, just hydration. Rare invasion of the bloodstream; bacteremia, septic shock. Caused by one serotype (salmonella enterica typhi) Rare in the us, still a problem worldwide. Some individuals develop chronic gall bladder infections. Shed millions of salmonella enterica typhi in their feces. The cause of massive pandemics throughout recorded history. 75% of those infected will never show symptoms.
