BIOC 406 Lecture Notes - Lecture 9: Cell Membrane, Cytosol, Adipose Tissue
Document Summary
Synthesis of glycogen: glucose-6-phosphate --> glucose-1-phosphate--> udp glucose--(glycogen synthase)--> glycogen. Glut 2 is the transporter that has low af nity for glucose. Adenylate cyclase hydrolyzed the beta and gamma phosphates from atp and built another ester bond between the 5-prime position and the 3-prime position to make camp. The hydrolysis of pyrophosphates makes this reaction favorable. Phosphodiesterase is an enzyme that breaks down camp, and caffeine inhibits it, so you have higher levels of camp. Epinephrine will bind to both muscle and liver; glucagon will bind only to liver. The liver uses the enzyme phosphatase to dephosphorylate glucose-6-phosphate and release free glucose into the blood. Muscles have beta-adrenergic receptors but no glucagon receptors camp activates camp-dependent protein kinase. It has two regulatory subunits and two catalytic subunits. -when camp binds, the pseudosubstrate that is there to prevent real substrates from getting in, no longer binds.
