NUTR 200 Lecture Notes - Lecture 15: Trans Fat, High-Density Lipoprotein, Atherosclerosis
Document Summary
Describe the main steps in the process of atherogenesis, the meaning and importance of foam cells, and the relaionship of ldl cholesterol levels to the process of atherosclerosis. List total and ldl cholesterol levels that increase risk of cardiovascular disease. Describe the efects of diets enriched with diferent faty acids (mufa, Risk factors for heart disease: high ldl cholesterol (bad cholesterol) Anatomy or artery wall and evoluion of atheroscleroic plaque. Atherogenesis the development and progression of atherosclerosis (heart disease) Cholesterol rich lipoproteins that migrate in and out of the artery wall from circulaion. Can become modiied (oxidized) in the artery wall and then do not return to circulaion. Macrophages immune cells that migrate into the artery wall to consume modiied ldl paricles. Macrophages that have consumed a lot of modiied ldl paricles. Accumulate in artery wall and eventually die leaving behind cell debris and cholesterol. Dietary fats that raise ldl cholesterol levels (when consumed in favor of other dietary fats)
