NPB 168 Lecture Notes - Lecture 2: Partition Coefficient, Lipophilicity, Pharmacokinetics
27 Apr 2016
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Crack and powder cocaine are exactly the same, except the prices differ. Treatment: little funding for efficacy of drug addiction treatment. Pharmacokinetics: movement of drug through the body, kinetics = time course of drug effect. Pharmacodynamics: interaction of the drug at the target site (receptor - molecular level, effects are initiated by drug-receptor binding, binding causes functional change in target cell initiated by the receptor, usually the binding is ionic and reversible. Components of pharmacokinetic process: drug administration (routes of administration) Nasal administration/snorting/insufflation (drug is being trapped in nasal mucosa which is absorbed into vascular system) All about absorption to get into the vascular system: absorption (getting on the bus aka cardiovascular system ) Drug must be able to cross membranes. Solubility: water soluble ionized, (+/- and must have a carrier), substance is hydrophilic. Oil/water partition coefficient (how much is drug in oily or water fraction) Degree of ionization at different phs for acids and bases.
