NPB 168 Lecture 5: NPB 168 Lecture 5

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Neurobiology,Physio & Behavior
NPB 168
Liets Lauren

NPB 168 Lecture 5  Potency as muscle relaxant vs. potency as analgesic, moderate positive correlation  Endogenous Opiates: Pro-Peptides o Pro-opiomelanocortin (binds to Mu and Delta)  Beta-Endorphins (B-END)  “our heroin” that is released when we exercise  Used for modulating pain o Proenkephalin (binds to Mu and Delta)  Neuromodulators o Prodynorphin (binds to Kappa) o Endomorphin (binds to Mu)  Functional neurotransmitter peptide  Termination of endogenous opiate signal o Peptidase  Endogenous Opiate Receptors o Au G-protein coupled receptors (metabatropic) o Mu Receptors  Most widely distributed in CNS  Effects  Analgesia (Periaqueductal gray, median raphe, spinal cord)  Reinforcement (Nucleus Accumbens, other limbic structures)  Autonomic Functions (Medulla, Area Postrema)  Euphoria (getting this response from reinforcement)  Opiates bind most strongly to this receptor, probably creating the rush or high o Delta Receptors  Less widely distributed in CNS  Effects:  Olfaction (olfactory bulbs)  Motor integration (Motor Cortex, Striatum, Substantia Nigra)  Analgesia (Brain Stem and spinal cord)  Reinforcement (Nucleus Accumbens) o Kappa Receptor  Least widely distributed in CNS  Effects:  Analgesia (PG, MR, SC, locus coeru
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