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Lecture 5

NPB 168 Lecture Notes - Lecture 5: Periaqueductal Gray, Area Postrema, Nippon Professional Baseball

3 pages100 viewsSpring 2016

Neurobiology,Physio & Behavior
Course Code
NPB 168
Liets Lauren

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NPB 168 Lecture 5
Potency as muscle relaxant vs. potency as analgesic, moderate positive correlation
Endogenous Opiates: Pro-Peptides
oPro-opiomelanocortin (binds to Mu and Delta)
Beta-Endorphins (B-END)
“our heroin” that is released when we exercise
Used for modulating pain
oProenkephalin (binds to Mu and Delta)
oProdynorphin (binds to Kappa)
oEndomorphin (binds to Mu)
Functional neurotransmitter peptide
Termination of endogenous opiate signal
Endogenous Opiate Receptors
oAu G-protein coupled receptors (metabatropic)
oMu Receptors
Most widely distributed in CNS
Analgesia (Periaqueductal gray, median raphe, spinal cord)
Reinforcement (Nucleus Accumbens, other limbic structures)
Autonomic Functions (Medulla, Area Postrema)
Euphoria (getting this response from reinforcement)
Opiates bind most strongly to this receptor, probably creating the rush or high
oDelta Receptors
Less widely distributed in CNS
Olfaction (olfactory bulbs)
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