Class Notes (1,016,007)
US (396,705)
UC-Davis (8,256)
NPB (221)
Lecture 5

NPB 168 Lecture Notes - Lecture 5: Periaqueductal Gray, Area Postrema, Nippon Professional Baseball

3 pages100 viewsSpring 2016

Department
Neurobiology,Physio & Behavior
Course Code
NPB 168
Professor
Liets Lauren
Lecture
5

This preview shows half of the first page. to view the full 3 pages of the document.
NPB 168 Lecture 5
Potency as muscle relaxant vs. potency as analgesic, moderate positive correlation
Endogenous Opiates: Pro-Peptides
oPro-opiomelanocortin (binds to Mu and Delta)
Beta-Endorphins (B-END)
“our heroin” that is released when we exercise
Used for modulating pain
oProenkephalin (binds to Mu and Delta)
Neuromodulators
oProdynorphin (binds to Kappa)
oEndomorphin (binds to Mu)
Functional neurotransmitter peptide
Termination of endogenous opiate signal
oPeptidase
Endogenous Opiate Receptors
oAu G-protein coupled receptors (metabatropic)
oMu Receptors
Most widely distributed in CNS
Effects
Analgesia (Periaqueductal gray, median raphe, spinal cord)
Reinforcement (Nucleus Accumbens, other limbic structures)
Autonomic Functions (Medulla, Area Postrema)
Euphoria (getting this response from reinforcement)
Opiates bind most strongly to this receptor, probably creating the rush or high
oDelta Receptors
Less widely distributed in CNS
Effects:
Olfaction (olfactory bulbs)
find more resources at oneclass.com
find more resources at oneclass.com
You're Reading a Preview

Unlock to view full version


Loved by over 2.2 million students

Over 90% improved by at least one letter grade.