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NPB 168 (5)
Lecture 5

NPB 168 Lecture 5: NPB 168 Lecture 5

3 Pages
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Department
Neurobiology,Physio & Behavior
Course Code
NPB 168
Professor
Liets Lauren

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NPB 168 Lecture 5
Potency as muscle relaxant vs. potency as analgesic, moderate positive correlation
Endogenous Opiates: Pro-Peptides
oPro-opiomelanocortin (binds to Mu and Delta)
Beta-Endorphins (B-END)
“our heroin” that is released when we exercise
Used for modulating pain
oProenkephalin (binds to Mu and Delta)
Neuromodulators
oProdynorphin (binds to Kappa)
oEndomorphin (binds to Mu)
Functional neurotransmitter peptide
Termination of endogenous opiate signal
oPeptidase
Endogenous Opiate Receptors
oAu G-protein coupled receptors (metabatropic)
oMu Receptors
Most widely distributed in CNS
Effects
Analgesia (Periaqueductal gray, median raphe, spinal cord)
Reinforcement (Nucleus Accumbens, other limbic structures)
Autonomic Functions (Medulla, Area Postrema)
Euphoria (getting this response from reinforcement)
Opiates bind most strongly to this receptor, probably creating the rush or high
oDelta Receptors
Less widely distributed in CNS
Effects:
Olfaction (olfactory bulbs)
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Description
NPB 168 Lecture 5  Potency as muscle relaxant vs. potency as analgesic, moderate positive correlation  Endogenous Opiates: Pro-Peptides o Pro-opiomelanocortin (binds to Mu and Delta)  Beta-Endorphins (B-END)  “our heroin” that is released when we exercise  Used for modulating pain o Proenkephalin (binds to Mu and Delta)  Neuromodulators o Prodynorphin (binds to Kappa) o Endomorphin (binds to Mu)  Functional neurotransmitter peptide  Termination of endogenous opiate signal o Peptidase  Endogenous Opiate Receptors o Au G-protein coupled receptors (metabatropic) o Mu Receptors  Most widely distributed in CNS  Effects  Analgesia (Periaqueductal gray, median raphe, spinal cord)  Reinforcement (Nucleus Accumbens, other limbic structures)  Autonomic Functions (Medulla, Area Postrema)  Euphoria (getting this response from reinforcement)  Opiates bind most strongly to this receptor, probably creating the rush or high o Delta Receptors  Less widely distributed in CNS  Effects:  Olfaction (olfactory bulbs)  Motor integration (Motor Cortex, Striatum, Substantia Nigra)  Analgesia (Brain Stem and spinal cord)  Reinforcement (Nucleus Accumbens) o Kappa Receptor  Least widely distributed in CNS  Effects:  Analgesia (PG, MR, SC, locus coeru
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