UWP 104F Lecture Notes - Lecture 4: Etiology

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harlequinoyster275

9 May 2019

School

UC-Davis

Department

University Writing Program

Course

UWP 104F

Professor

Bill Sewall

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Document Summary

How/where does it originate: use scientific wording. Epidemiological information is used to plan and evaluate stra tegies: evidence can only show that this risk factor is associated (correlated) with a higher incidence of disease in the population exposed to that risk factor. Etiology: "giving a reason for, the cause, set of causes, or manner of causation of a disease or condition, origin of a disease, cause or causes, possible origins. List any data or findings that may explain the cause of the disease: we still do not know the exact cause of many diseases. Make sure to mention if the listed cause or causes are hypotheses or n ot.

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PLEASE ANSWER ALL QUESTIONS..PLEASE NOT ONLY 1 QUESTION. THANK YOU

QUESTION 1. Chronic diseases generally have several underlying characteristics, including a.A long latency period between exposure to risk and disease outcomes b. Low degree of preventability c. High curve rate d.None of the above

QUESTION 2.Which of the following risk factors collectively explain a significant proportion (not incidence) of most chronic diseases. a.Tobacco, alcohol, diet b.Tobacco, alcohol, diet, physical activity c. Alcohol, physical activity d.Tobacco, diet, physical activity

QUESTION 3.Adherence to treatment is influenced by several interacting dimensions including a.Social and economic factors b. Healthcare system factors c.Condition-related factors d.Therapy-related factors e.Patient related factors f.All of the above

QUESTION 4. _________ is the leading cause of cancer in both developed and developing countries worlwide a.Radiation exposure b. Tobacco use c.Pesticide exposure d.Air pollution

QUESTION 5.This week's YouTube video on treating non-communicable diseases in Rwanda showed how a community health worker helps to treat heart disease, diabetes and _______ a.Cancer b.Asthma c.Hepatitis d.HIV/AIDS

QUESTION 6.Which of these are myths of chronic disease control a.Benefits of chronic disease control accrue not only to the individual but also to the population b.Economic growth improves all health conditions c. Chronic diseases are associated with low SES/poverty d.Chronic disease only occurs in the elderly e.a and c f.b and d

QUESTION 7 ___________ remains the leading cause of death among both men and women in low- and middle-income countries a.Cancer b.Cardiovascular disease c. Diabetes d.Obesity e.Respiratory disease

QUESTION 8.Chronic disease in adults accounts for approximately 60% of all deaths worldwide. True False

QUESTION 9.The WHO's Innovative Care for Chronic Conditions Framework includes a positive policy environment. True False

QUESTION 10.It is estimated that the overall number of cancer cases will rise by 50% in the next 20 years. True False

QUESTION 11.Comorbidity refers to simultaneous occurrence in a person of two or more disorders; comorbid conditions can increase the risk of adverse outcomes. True False

QUESTION 12.Emerging evidence supports starting promotion efforts during pregnancy and early childhood and continuing efforts throughout life lower exposures to major chronic disease risk factors. True False

QUESTION 13. Increased cumulative exposure to risk factors over the lifecourse combined with social and economic inequalities, leads to the levels of inequalities seen in later adult life. True False

QUESTION 14.The "compression of morbidity" model proposes that morbidity due to aging cannot be postponed or mitigated by disease prevention programs True False

QUESTION 15.There is few significant funding sources for chronic diseases in low-and middle-income countries. True False

QUESTION 16.To combat chronic diseases, modern, evidence-based interventions emphasize shared decision making and collaborative goal setting among providers and patients. True False

QUESTION 17.In the absence of legislative, financial and engineering approaches, health education programs often have a limited impact on preventing or reducing chronic diseases. True False

QUESTION 18. It is estimated that deaths from diet-related chronic disease in China will triple between 1995 and 2025. True False

QUESTION 19.The third highest percent of global DALY's is attributed to which risk factor? a.Alcohol use b.Tobacco use c.Unsafe sex d.Childhood underweight

QUESTION 20.In the 1990's which country experienced a substantial decline in male life expectancy as a result of dramatic socio-political changes a.China b.Russia c. India d.Canada

jademole302

1. The risk of acquiring disease is measured by the

a. Incidence rate

b. Incidence rate times the average duration of the disease

c. Incidence rate divided by the prevalence rate

d. Prevalence rate

e. Prevalence rate times the average duration of the disease

2. The strength of an association between a factor and a disease is best measure by .

a. Incubation rate

b. Incidence of the disease in the total population

c. Prevalence of the factor

d. Attributable risk

e. Relative risk

3. Case fatality rate for a given disease refers to

a. The crude mortality rate per 100,000 population

b. Cause-specific mortality rate due to the disease

c. A fatal outcome of any disease

d. The percentage of deaths among cases of the disease

e. The proportion of deaths due to the disease among all deaths from all causes

4. An investigator is interested in etiology of neonatal jaundice. To study this condition, he selected 100 children who were diagnosed with this condition and 100 children born in the same period and in the same hospital who did not have a diagnosis of neonatal jaundice. He then reviewed the obstetrical and delivery records of their mothers to determine various prenatal and perinatal exposures. This is an example of a(n):

a. Cross-sectional study

b. Case-control study

c. Cohort study

d. Clinical trial

e. Experiment

5. Which of the following statements describes the major advantages of a randomized clinical trial?

a. It avoids observer bias

b. It lends itself to ethical justification

c. It yields results replicable in other patients

d. It rules out self-selection of participants to the different treatment groups

d. It enrolls representative patients

a. Correct b.

Incorrect because of failure to distinguish between incidence and prevalence

c. Incorrect because a proportionate ratio is used when a rate is required to support the inference

d. Incorrect because a failure to recognize a possible cohort phenomenon

e. Incorrect because there is no control or comparison group.

7. An investigator determines the correlation coefficient between triglyceride levels and degree of atherosclerosis in sampled blood vessels to be +1.67. On the basis of this you would conclude that:

a. Triglyceride level is a good predictor of atherosclerosis

b. Triglyceride level is not a good predictor of atherosclerosis

c. High triglyceride levels cause atherosclerosis

d. Atherosclerosis cause high triglyceride levels

e. The investigator has incorrectly determined the correlation coefficient

a. The percent of all negative tests that have false-negative results is lower in population A than in population B.

b. Specificity is lower in population A than in population B.

c. Reliability is higher in population A than in population B.

d. The percent of all positive tests that have false-positive results is lower in population A than in population B.

e. Specificity is higher in population A than in population B.

9. Serum cholesterol levels are obtained for four healthy men. The probability that all will fall below the 10th percentile of the distribution of cholesterol for healthy males is:

a. 0.4

b. 1 â (0.1)4

c. (0.1)4

d. (0.9)4

e. Cannot be determined from these data

10. In a diabetes screening program, the screening level for a positive blood sugar level in test 1 is set at 160 mg/dl, and in test 2 at 130 mg/dl. The sensitivity is:

a. Greater in test 1

b. Greater in test 2

c. Equal in test 1 and 2

d. Dependent on the size of the population being evaluated

1. The risk of acquiring disease is measured by the a. Incidence rate b. Incidence rate times the average duration of the disease c. Incidence rate divided by the prevalence rate d. Prevalence rate e. Prevalence rate times the average duration of the disease

2. The strength of an association between a factor and a disease is best measure by a. Incubation rate b. Incidence of the disease in the total population c. Prevalence of the factor d. Attributable risk e. Relative risk

3. Case fatality rate for a given disease refers to a. The crude mortality rate per 100,000 population b. Cause-specific mortality rate due to the disease c. A fatal outcome of any disease d. The percentage of deaths among cases of the disease e. The proportion of deaths due to the disease among all deaths from all causes

5. Which of the following statements describes the major advantages of a randomized clinical trial? a. It avoids observer bias b. It lends itself to ethical justification c. It yields results replicable in other patients d. It rules out self-selection of participants to the different treatment groups d. It enrolls representative patients

6. A survey conducted in England revealed that of 224 families in which there had been a known case of poliomyelitis, 56 maintained parakeets as a family pet. In another British survey, 30 out of 99 poliomyelitis patients questioned kept parakeets. The inference that there is some relationship between the presence of a parakeet in a household and the occurrence of poliomyelitis among household members is a. Correct b. Incorrect because of failure to distinguish between incidence and prevalence c. Incorrect because a proportionate ratio is used when a rate is required to support the inference d. Incorrect because a failure to recognize a possible cohort phenomenon e. Incorrect because there is no control or comparison group.

7. An investigator determines the correlation coefficient between triglyceride levels and degree of atherosclerosis in sampled blood vessels to be +1.67. On the basis of this you would conclude that: a. Triglyceride level is a good predictor of atherosclerosis b. Triglyceride level is not a good predictor of atherosclerosis c. High triglyceride levels cause atherosclerosis d. Atherosclerosis cause high triglyceride levels e. The investigator has incorrectly determined the correlation coefficient

8. A screening test of known sensitivity and specificity is applied to two populations. The prevalence of the disease being screened for is 10% in population A and is 1% in population B. Which of the following is true? a. The percent of all negative tests that have false-negative results is lower in population A than in population B. b. Specificity is lower in population A than in population B. c. Reliability is higher in population A than in population B. d. The percent of all positive tests that have false-positive results is lower in population A than in population B. e. Specificity is higher in population A than in population B.

9. Serum cholesterol levels are obtained for four healthy men. The probability that all will fall below the 10th percentile of the distribution of cholesterol for healthy males is: a. 0.4 b. 1 â (0.1)4 c. (0.1)4 d. (0.9)4 e. Cannot be determined from these data

10. In a diabetes screening program, the screening level for a positive blood sugar level in test 1 is set at 160 mg/dl, and in test 2 at 130 mg/dl. The sensitivity is: a. Greater in test 1 b. Greater in test 2 c. Equal in test 1 and 2 d. Dependent on the size of the population being evaluated

Part II 1.The California Occupational Mortality study data set was employed to assess mortality data for the years 1979-1981. A 2% sample of employed persons from the 1980 census of California was used. It contains the occupation of each person who had died. This study, like any occupation-based study, is restricted to the work life span as far as age of subjects is concerned. This study used ages 16-64 years. Certain persons, because of their source of work, were excluded as subjects: homemakers, retired persons, students, disabled, military personnel, etc. Only main-stream-type employment was used in this study to establish occupations at risk for heavy alcohol drinking. Using the Table below, answer the following:

1.What occupations are most vulnerable to acquiring cirrhosis of the liver from heavy drinking?

2.List several of the occupations identified by the research studies that are more vulnerable to alcohol-induced, cirrhosis related deaths and that have the highest mortality rates.

3. What are possible confounding variables for the research in occupations and heavy drinking that lead to fatal diseases?

4. Based on available research data, develop and construct a web of causation along with the appropriate decision trees for occupational group-related alcohol deaths. Table. Alcohol Related Deaths in California, 1979-1981 Cirrhosis 5.5% Digestive organ cancers 5.7% Injuries 13.7% Suicide and homicide 5.% All other causes 64.9%

Zika and microcephaly Since May 2015, Brazil has experienced a significant outbreak of Zika virus. In recent years, Brazilian officials reported an increase in the number of babies born with microcephaly.

1. Briefly describe what we know and what we do not know about Zika virus.

2. What has been done and what should be done to prevent Zika virus epidemic in US and world-wide?

UWP 104F Lecture Notes - Lecture 4: Etiology

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