BIO SCI 45 Lecture Notes - Lecture 3: Aids, Hiv Vaccine, Opportunistic Infection
5 Oct 2016
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Document Summary
Choices for initiation of art: initiate as soon as possible, reduce viral loads, slow progression of immunological defects, particularly effective if diagnosis during initial acute infection, art may reduce the viral set point. Viral set points correlated with rate of progression to disease: treatment of hiv-infected people with art substantially decreases likelihood for infecting others, delay initiation, continue art lifelong once it is initiated, drug-resistant virus may develop. Specific art combination not available if drug-resistance virus develops: reduce drug side effects from prolonged treatment. Individuals with full-blown aids (cd4 counts below 200: substantial risk for opportunistic infections, treat prophylactically with antibiotics (prevent infection) Pneumocystis pneumonia is a common oi: preventative trimethoprim and sulfamethoxazole (bactrim) Art for a fixed time to prevent establishment of infection. Exposure of healthcare worker (needle stick, hiv+ blood) Lack of a convenient animal model system = major stumbling block: would improve testing vaccines and therapies.
