BIO SCI 93 Lecture Notes - Lecture 7: Nuclear Lamina, Intermediate Filament, Progeria

• School: UC-Irvine
• Department: Biological Sciences
• Course: BIO SCI 93
• Professor: Busciglio/ Wood/ Green

Document Summary

Lecture 7: cytoskeleton, mitocondria, chloroplasts, and extracellular matrix. (+) plus end and a (-) minus end. Ex. microvilli increase the absorbing area of intestinal cells. Different subunits depending on cell type (e. g keratins, neurofilaments, etc) Lamin mutations cause accelerated aging in humans (progeria) Lamin mutations lead to alterations in nuclear assembly, architecture, and chromosome organization. Kinesins (moves toward the (+) end of the mt) Note: in animal cells the microtubule organizing center (mtoc) has two centrioles. Bind to the cargo and the cytoskeletal polymer. Adapter region that is specific for each cargo. In unattached cells, they move cells from one place to another. In attached cells, it moves fluid over tissue. Animal tissues have a complex extracellular matrix mainly composed of glycoproteins (secreted by the cell)-most abundant:collagen fibers. Integrins in the plasma membrane link ecm proteins such as fibronectin with the cellular cytoskeleton, facilitating the crosstalk between the cell and its environment.