BIO SCI 94 Lecture Notes - Lecture 5: Dwarfism, Dna Replication, Gout

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BIO SCI 94 Full Course Notes
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BIO SCI 94 Full Course Notes
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Terms: allele, allele frequency, genotype, genotype frequency, homozygote, heterozygote, dominant. Hardy-weinberg equilibrium: random mating, no natural selection, no genetic drift - infinite population size, no gene flow, no mutation. New generation: p" = p2 + pq = p q" = pq + q2 = q. If they are in hw proportions, we cannot conclude that natural selection, genetic drift, gene flow, mutation, or non-random mating are occurring. How does selection change the hwe: example: the agouti gene in mice, aa: agouti coat, aay yellow coat, ayay: recessive lethal. How does non-random mating change the hwe: the most severe type of non-random mating is self-fertilization (mate w/ yourself, example: *from prof. gaut"s notes: thus, inbreeding increases homozygosity, non-(cid:396)a(cid:374)do(cid:373) (cid:373)ati(cid:374)g ge(cid:374)e(cid:396)ally does(cid:374)"t i(cid:374)(cid:272)(cid:396)ease allele f(cid:396)e(cid:395)ue(cid:374)(cid:272)ies (cid:271)ut , non-random mating changes genotype frequencies away from hw proportions. Hwe assumptions: no natural selection, no inbreeding (selfing, no genetic drift, no gene flow, no mutation.

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