BIO SCI 97 Lecture 24: Lecture 24 Notes
22 Dec 2018
School
Department
Course
Professor
Document Summary
It can be inherited - often as a predisposition to cancer. It mostly involved genome/ epigenome changes in the soma. Cancers develop overtime in a process analogous to evolution. Malignant cells - divide without control and evade other tissues. Tumorigenesis - the formation of an abnormal mass of cells, aka a tumor. Carcinogenesis - the formation of a cancerous cell. Carcinoma - a tumor arising in an epithelial tissue (skin, lung, pancreas) Malignant tumors stimulate the production of new blood vessels to provide the tumor with oxygen and nutrients required for prolific growth. The normal (proto oncogene) alleles encode proteins that tell the cell to grow and divide in response to specific signals. The mutated (oncogene) alleles tell the cells to grow and divide all the time - even when there is no permission signal. Brakes for cell division or caretakers of genome integrity. Mutation brakes don"t work or mutations/ rearrangements accumulate.
