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Lecture 9

D103 - Lecture 9 - Cells In Their Environment.docx

5 Pages
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Department
Biological Sciences
Course Code
BIO SCI D103
Professor
Grant Mac Gregor

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A. Clicker
a. Interphase
i. Nuclear lamina occurs at the edge of the nuclear envelope
b. Phosphorylation of lamins to break apart nuclear membrane
i. Mutation
1. Cells will not be able to segregate DNA
b. Mutate serine to an alanine
i. Dominant negative
i. Prevent phosphorylation
1. Negative charge
ii. Use glutamic acid or aspertate
1. Dominant active
B. Extracellular matrix
a. Basal lamina
b. Collagen fibrils
i. Determines the characteristics of the ECM
1. Rope-like - tendons
2. Transparent - cornea
3. Calcified - bone
b. Created by the cells in the ECM
i. Determines the characteristics of the ECM
B. Basal Lamina
a. Separates connective tissue from the cell layer
b. Organization is cell specific
i. Muscle all cells are surrounded
ii. Blood Brain Barrier
b. Laminin
i. heterotrimer
ii. Provides binding sites for a lot of proteins
iii. Adhesion protein
b. Collagen IV
i. Heterotrimer
ii. Only found in the basal lamina
iii. Mesh structure
B. Connective Tissues
a. Mostly made of ECM, not CELLS
b. Contains many insoluble fibers
i. Collagen
ii. GAGs
iii. Proteoglyans
iv. Elastin
v. Adhesive proteins
b. Actively remodeled
i. Remodeled by metalloproteases
b. Glycine-X-Y
i. Glycine in every third position
ii. In all collagens
iii. Proline and Lysine - get hydroxylated

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Description
A. Clicker a. Interphase i. Nuclear lamina occurs at the edge of the nuclear envelope b. Phosphorylation of lamins to break apart nuclear membrane i. Mutation 1. Cells will not be able to segregate DNA b. Mutate serine to an alanine i. Dominant negative i. Prevent phosphorylation 1. Negative charge ii. Use glutamic acid or aspertate 1. Dominant active B. Extracellular matrix a. Basal lamina b. Collagen fibrils i. Determines the characteristics of the ECM 1. Rope-like - tendons 2. Transparent - cornea 3. Calcified - bone b. Created by the cells in the ECM i. Determines the characteristics of the ECM B. Basal Lamina a. Separates connective tissue from the cell layer b. Organization is cell specific i. Muscle all cells are surrounded ii. Blood Brain Barrier b. Laminin i. heterotrimer ii. Provides binding sites for a lot of
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