BIO SCI D103 Lecture Notes - Lecture 17: Cytochrome C Oxidase Subunit Ii, Alpha Helix, Gtpase
18 Mar 2014
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Document Summary
No gap = signaling would occur for a longer period of time. Causes conformational change in the primary binding site. Gtpase are only active when they are gtp bound. Key in allowing these molecules to act as signaling molecules. Beta ii: gamma, has lipid modifications b. i. ii. Beta/gamma: helps to shut down the alpha subunit, can also signal things. Gdp is released from the alpha, and gtp binds to the alpha. Gtp causes another conformational change in the alpha subunit. Conformational change could lead to complete separation of the a. b. change in the alpha subunit c. d. e. alpha from the beta/gamma subunit f. alpha subunit interacts with the target protein g. h. beta/gamma subunits. Target protein acts as the gap for hydrolyzing the gtp. Gdp-alpha subunit causes the alpha to recombine with the. Targets for g-proteins a. b. c. d. a. Gi and gs affect adenylyl cyclase a. b.
