BIO SCI E182 Lecture Notes - Axon Hillock, Membrane Potential, Cell Membrane

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Transient/ weaker as you get farther from the stimulus (distance-dependent) May assume that ion concentrations do not change appreciably as ions migrate across membrane changing membrane potential. A significant change in membrane potential requires the movement of very few ions to change the membrane potential by 100mv, only one out of every 100,000 k+ must enter or leave the cell. This is such a tiny fraction of the total number of k+ ions in the cell that the concentration gradient for k+ remains essentially unchanged pg. For purposes of calculating ion concentrations, you may always assume that any fluid compartment is electrically neutral (the number of positive charges=number of negative charges) For example, if [na+] is 0. 1 mm, you should assume that negative charges are also 0. 1mm. The only cation is ca++ and the only anion is cl-. For every ca++, we need 2cl- : 0. 2 moles of cl- are needed.

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