BIO SCI 38 Lecture Notes - Lecture 16: Tricyclic Antidepressant, Serotonin Transporter, Dopamine Receptor
18 Jul 2016
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Document Summary
Recreational drug use - first evidence of human use ~6000-8000 bc. Medical use - homeopathic & traditional medicine - cannabis, opium, tobacco. Endogenous ligand - nt in the brain that normally binds receptors. Exogenous ligand - drugs that binds to receptor causing similar action as endogenous ligand. Competitive antagonist - drug that binds & blocks endogenous ligand from binding. Allosteric modulator - drug that binds to diff site on the receptor from endogenous ligand, altering its effect. Enzymatic degradation - some nts are metabolized by enzymes. Transporters on presynaptic axon terminals reuptake nt. Mental illness isn"t new - historically been blamed on faulty rearing, spiritual weakness, demonic possession, etc. Reserpine - traditional indian medicine, depletes monoamines & treats mania. Treat positive schizophrenia symptoms (hallucinations, thought disturbance, etc) Increase synaptic levels of monoamines by blocking mao, an enzyme that degrades them. Lithium forms a salt licl - used as a table salt during wwii.
