BIO SCI D103 Lecture Notes - Lecture 14: Ubiquitin-Conjugating Enzyme, Ubiquitin Ligase, Ldl Receptor
18 Mar 2014
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Consequence of phosphor-mimetic mutation (dominant positive) in lamin i. ii. iii. Intermediate filaments need to be phosphorylated to disassemble. Similar to hutchinson-gilford progeria: sec 23/24, clathrin. Requires a adaptor protein to recruit cargo i. At the tgn: fh patients (familial hypercholesterolemia, mutation in the sorting signal in the ldl receptor b. c. Ldl receptor cannot bind to the clathrin to be endocytosed. Ldl can still bind to the ldl receptor (stays at the membrane surface: lysosome. Acidic, pumps protons into the lysosome ph dependent enzymes i. Gets rid of membrane receptors by budding into the endosome. Lyosome binds: autophagy degrades cytosolic proteins and organelles. Autophagic vesicle fuses with the lysosome: proteasome a. A a. a. b. a. b. b. b. a. b. a. b. b. c. a. b. b. b: ubiquitination. Creates isopeptide bonds between lysines, and terinal glycine of c. Can be attached at any of its 7 lysines i. Pushed vesicle into the endosome: posttranslational modification of proteins.
