BIO SCI D103 Lecture Notes - Lecture 19: Fibrodysplasia Ossificans Progressiva, Cytokine Receptor, Proteoglycan
18 Mar 2014
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Document Summary
Receptors can have built in kinase ability or associated ones. Single-pass transmembrane receptor a. undergo conformational change b. Ligand induces dimerization or causes a preformed dimer to i. Proteoglycan has sugar molecules that attracts and binds to ligands (type ii, rii) Ligand binds to rii, rii"s kinase is always on, ri comes closer to i. Rii, rii phosphorylates ri, ri-p phosphorylates r-smad at 3 ser, Nls is exposed on r-smad, r-smad bind to other r-smads by mh2 domain and phosphorylated serines, importin binds with r-smad + co-smad, smad/importin complex enters the nucleus, importin leave. Smad, smad forms a transcriptional complex b. b. b. i. i. i. Normally inactive kinase, but binding to r2: r1 gets phosphorylated by r2, r-smad binds to the r1 phosphorylated a. b. B: r-smad, has mh2 and mh1 a. 3 serines get phosphorylated and reveals nls: co-smad helps to form the heterotrimer of smads, not phosphorylated, r-smad+importin+co-smad.
