BIO SCI D103 Lecture Notes - Cdk Inhibitor, Spindle Checkpoint, Cyclin D

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B. a. a. b. a. b. c. b. b. a. a. a. b. b. b. a. a. b. c. d. a. i. i. ii. iii. i. ii. iii. iv. i. ii. i. i. i. i. i. Kinase must be bound to cdk and bound to cyclin. Ubiquination of cyclin to cause destruction by lysosome, every cell cycle stage. G0-> g1 go from in inhibitory state to a developing state. Rb, binds to e2f and sequesters it from acts as transcription factor. Inactivate cyclin-cdk complex by binding of an inhibitor. Make sure all the chromosomes are captured correctly. Dna breakage leads to free ends of dna. Usually has a telomere at the end of the dna. Active when cyclin is bound i. i. i. ii. i. i. ii. iii. i. ii. iii. iv. v. Must pass a threshold of m-cyclin concentration d. i. M-cdk must be turned off before mitosis completion. Cyclins activate cdk, bust also directs cdks to targets.

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