BIO SCI D103 Lecture Notes - Lecture 12: Calnexin, Protein Targeting, Mitochondrial Matrix

49 views4 pages

Document Summary

B. i. i. i. ii. i. ii. i. ii. i. ii. iii. i. i. i. ii. iii. ii. iii. Mitochondrial import: everyone needs to go through tom. Must be unfolded: having a sorting signal. Only affects proteins going into the mitochondrial matrix. Clicker questions: how would this protein be inserted into the membrane (er membrane) N-terminus in er lumen, c-terminus in er lumen: extra srp proteins aren"t required for more transmembrane domains, based on the first transmembrane domain. Coat will fall apart after the gtpase leaves a. Import into the er occurs co-translationally: glycosylation also occurs co-translationally. Events in the er: no disulfide bonds in the cytosol. Has a sugar tree with 3 glucose at the end. To allow it to leave the er b. Can reglycosidate to tell the protein to refold again i. Increases the transcription of chaperones and folding: retrotranslocated back into the cytosol. Cystic fibrosis: characterized by thick mucus buildup, disregulation of water metabolism, cftr.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related textbook solutions

Related Documents

Related Questions