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University of California - Irvine
Biological Sciences
Peter A.Bowler

e109 11/21/12 LanceArmstrong in the News EPO increases the number of red blood cells in the circulatory system, which carry oxygen EPO would increase the red blood cell count, which would increase your oxygen carrying capacity Riders would inject saline and plasma infusion to avoid detection of unusually high hematocrit Oxygen-hemoglobin dissociation curve==loading and unloading -the line is much steeper in the bottom (not a straight line) -partial pressure of oxygen in a resting cell is 40 mmHg and 100 mmHg in alveoli -binding of oxygen by hemoglobin is a reversible reaction—needs to have a decrease in saturation level to unload the oxygen to the tissues Effect of pH pH 7.4 is considered normal (facilitates the unloading of oxygen from hemoglobin)-around 22 mmHg -If the pH is higher or lower than 7.4, then this changes the binding of oxygen to hemoglobin -Alower pH (more acidic) would unload more oxygen -Ahigher pH (more basic) would unload less oxygen 100mmHg in the lungs At higher temperatures, oxygen unloading in the tissues is facilitated. False At higher temerpatures, oxygen loading in the lungs is facilitated. True Chronic hypoxia leads to increase in 2,3-DPG in red blood cells hemoglobin packaged inside red blood cells, so the conditions inside the red blood cells affect the hemoglobin affinity Chronic hypoxia: long-term/chronic exposures to long-term lack of oxygen (exposure to high altitudes)—environments in which there are low levels of oxygen causes EPO to increase the red blood cell count and 2,3-DPG is added to both increase your oxygen carrying capacity Fetal vs. Maternal hemoglobin Fetal hemoglobin: does not have direct access to the outside world and reliant on mom for oxygen supply; oxygen will move from mother’s blood to bab’s blood (as the two are brought in close proximity____) Effects of high altitude at higher altitude b/c the overall pressure is lower, so the partial pressure of oxygen is lower -sea level, total pressure is 760 mmH (Partial pressure of oxygen is 159 mmHg) 3000 m high, reduction in physical performance Decreasing pressure with increasing altitude means lower partial pressure of oxygen Scuba diving -Have to breathe pre
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