BIO SCI M114 Lecture Notes - Lecture 7: Trypsin, Ribonuclease, Hydrophile
12 Mar 2014
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Amphensen"s dogma - 3d structure of protein = function. Though this is not always true, not all proteins can be denatured and refolded. Looking at all the hemoglobin, the 3d structure for all of them look very similar. The backbone is very similar in size & shape. But the variation of amino acid sequence also matters. This tells us that different sequence of amino acids can produce a similar structure. The high identity among protein tells us that they produce a similar structure. Thus there is a tremendous redundancy across proteins, as long as the structure is okay and key amino acids in the important location, the backbone sequence may not have to be exactly the same. Conserved residues are regions where his (the active site) and the cysteine (s-s) We can determine the phylogenetic relationship by looking at the redundancy of amino acid sequence across species. Then diverges, creates similar but different dehydrogenases with similar function.
