Lecture 11.docx

5 Pages
66 Views
Unlock Document

Department
Biological Sciences
Course
BIO SCI M114
Professor
Alexander Mc Pherson
Semester
Spring

Description
Lecture 11 02/13/2014 Quaternary Structure  Enzyme complexes Allosteric regulation Get differential activity even from the different chains Ex. Hemoglobin: not all chains bind to oxygen with the same affinity Bhor’s effect – sigmoidal curve The binding of one heme, effects another; conformational change and subsequent changes Modulation of the enzyme activity by multiple subunits Concentration [clustering] of Active sites Moves the ligand to the next active site without having to move it across the cytoplasm is more efficient for  the cell Size considerations Proteins circulating throughout the serum gets filtered in the kidney if they are too small – thus bigger  proteins do not get filtered out Isozymes – Modulation of activity Same protein, different tissue, different activity Or different binding affinity (Km) or Turnover rate Gene A and Gene B form a tetramer Ex. AAAA, BBBB, AABB, ABBB, AAAB Range of different activity but composed of same units Formation of large complexes Self assembly/coopertivity Formation of a trimer promotes a tetramer It is easier to make small subunits and put them together, rather than forming one long peptide chain Less errors Need a long gene, rather just 1 small gene forming subunits Symme
More Less

Related notes for BIO SCI M114

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit