BIO SCI N153 Lecture Notes - Lecture 5: Basal Ganglia, Vesicular Monoamine Transporter 1, Aromatic L-Amino Acid Decarboxylase
22 Apr 2018
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Chapter #5: (slides 1-29: catecholamine, catecholamines, group of neurotransmitters and hormones characterized by two chemical similarities: a core structure of catechol and a nitrogen- containing amine. They belong to a wider group of transmitters called monoamines or biogenic amines: who"s i(cid:374)(cid:272)luded, dopamine (da, norepinephrine (ne) aka noradrenaline, epinephrine (epi) aka adrenaline, picture. 2: tyrosine + th dopa, dopa + aacd dopamine, dopamine + dbh norepinephrine, norepinephrine + pnmt epinephrine. Catecholamine storage and release: vesicular monoamine transporter (vmat, responsible for the uptake of catecholamine into the vesicles, vmat1: found in the adrenal medulla, vmat2: found in the brain, these (cid:448)esi(cid:272)ular tra(cid:374)sporters are (cid:271)lo(cid:272)ked (cid:271)y the drug (cid:862)reserpi(cid:374)e(cid:863). When this drug is given, da and ne are no longer protected from breakdown. 3 by enzymes within the nerve terminal, which causes the level of both transmitters in the brain to drop very low.
