CHEM 51C Lecture Notes - Lecture 3: Organolithium Reagent, Gilman Reagent, Organometallic Chemistry
Document Summary
Main learning goal: tutees will be able to approach carbonyl addition reactions involving organometallic reagents and apply the knowledge in synthesis problems. Mini learning goal 1: tutees will review how alkyl halides are converted into good nucleophiles. Mini learning goal 2: tutees will be able to produce the mechanisms of the reactions involving carbonyls and organometallic reagents. How to make grignard reagent from alkyl halide. How to make organolithium reagent from alkyl halide. How to make organocuprate reagent from alkyl halide [we won"t talk about this reagent today: make a organolithium reagent, make another organolithium reagent (2 r-li total) Metals are very electropositive= carbons are way more electronegative. Organometallic reagents= a good way to make c-c bonds: other ways to make c-c bonds: Reactions on aldehydes and ketones makes alcohols (similar to lialh4 and nabh4) Step-by-step mechanism for carbonyl compounds with organometallic. Reagents and acetylide: check your carbonyl compound. a.
