PUBHLTH 147 Lecture Notes - Lecture 10: Drug Diversion, Goose Bumps, Fentanyl
14 Mar 2017
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Document Summary
Current laws in the us: schedule i heroin, schedule ii - morphine, opium, codeine, oxycodone (oxycontin, percocet), etc, schedule v robitussin ac containing codeine. Medical uses for opiates: various routes of administration, oral (pills, transdermal (patch for pain) Inhalation, intranasal and injection- more common with illicit use: needle exchange programs decrease risk of disease transmission. Acute effects: objective effects, decreased activity, sedation and sleepiness, decreased signs of pain (less grimacing, moaning, etc. , cognitive impairments, speech slurred, confusion, poor judgment, less sociable and less talkative, decreased sex drive, subjective effects. Lethal dose: opiates can easily lead to overdose and death, suppress respiration. Increased sensitivity to pain: dependence, greater risk of early death. Impotence: weight loss, chronic constipation, neurocognitive deficits (e. g. , problem solving, memory) Tolerance: extremely quick development of tolerance, tolerance to euphoria, respiratory suppression, chronic user can use amount that would cause death in a casual user, reverses with abstinence, no tolerance to constipation, biological and learning mechanisms involved in tolerance.
