PUBHLTH 147 Lecture Notes - Lecture 13: Iproniazid, Tachycardia, Selective Serotonin Reuptake Inhibitor
14 Mar 2017
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What are antidepressants used for: researchers/physicians believe that antidepressants correct imbalances in our brain that probably contribute to disturbances in mood/behavior, also used in some cases of bipolar disorder and anxiety disorder. Joh(cid:374)"s wort: witches, evil spirits, and melancholia (aka depression, described in medical literature dating back to 400 bc, treat(cid:373)e(cid:374)t for (cid:862)(cid:374)er(cid:448)ous disorders(cid:863) i(cid:374) the 1800s, still used as an antidepressant today. History of antidepressants: 400 bc and onward t. In general terms, antidepressants work either by increasing the amount of neurotransmitters released by the sender, or decreasing the amount of neurotransmitters recycled by the sender. Major types: monoamine oxidase inhibitors (maois, tricyclic antidepressants (tcas, selective serotonin reuptake inhibitors (ssris, serotonin and norepinephrine reuptake inhibitors (snris, selective norepinephrine and dopamine reuptake inhibitors (ndris, selective norepinephrine and dopamine releasing agents (ndras) Side effects maoi: maois affect norepinephrine, epinephrine, serotonin, and dopamine, maois are the oldest and have the most side effects.
