HSC 4555 Lecture Notes - Lecture 22: Gas Exchange, Thoracic Cavity, Antibiotics
Document Summary
Wall of the lumen has the issue- this is what is causing the obstruction. Swelling and inflammation of actual linings will see excess mucous production. And the muscles around the airways itself will tighten. Intrinsic: tends to develop after repeated exposure to allergen (ex: occupational asthma- work in a factory with repeated exposure to gas) Type i -ige mediated figure out what you are allergic to normally a family history for extrinsic. Small lumen- result of inflammatory response smooth muscle becomes hypertrophy, excess mucous, hyperplasia of mucous glands. Accumulation of mucous in the lumen-excess goblet cells. Actual airway wall begins to denude away and loose actual surface area of the wall. Phase 3- normal respiratory epithelium is denuded (loss of outside layer) and replaced by goblet cells. Mucous casts: takes the shape of the airway mucous plug in the shape of the airway (inside cast) comes out as the inner shape of the pathway.
