HSC 4558 Lecture Notes - Lecture 9: Malar Rash, Osteoarthritis, Lyme Disease

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29 Apr 2016
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Chapter 52: alterations in musculoskeletal function: rheumatic disorders. Osteoarthritis is a local degenerative joint disorder associated with aging and wear and tear from repetitive stress. Oa is characterized by loss of articular cartilage, wear of underlying bone, and the formation of bone spurs. Signs and symptoms of oa are localized (not systemic) and include joint pain and crepitus with movement. Joint infection may be due to a variety of infectious agents, but bacteria are the most problematic. The route of infection is usually by way of the bloodstream. Signs and symptoms are due to localized infection and the systemic manifestation of inflammation. A number of immune-mediated systemic connective tissue diseases result in joint dysfunction, including ra, sle, and scleroderma. Most are classified as autoimmune disorders of unclear cause. The signs and symptoms of systemic joint disorders are generalized but involve multiple joints and usually other connective tissue structures.

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