NUR 3145 Lecture Notes - Lecture 10: Pericardial Effusion, Diabetes Insipidus, Isosorbide Mononitrate
Document Summary
Site of action - loop of henle. Usually given first thing in morning, possibly early afternoon lasts 8 hrs lasts 2 hrs. Function like loop diuretics: but, will not work in renal impairment. Site of action early distal convoluted tubule. Po onset 2 hrs, peak 4-6, lasts up to 12 hrs. Po onset 24-48 hrs, lasts 48-72 hours. Po onset 2-4 hrs, lasts 12-16 hrs. Aes hyperkalemia, n/v, leg cramps, dizziness amiloride [midamor] Site of action proximal convoluted tubule. Iv onset 30-60 min, lasts 6-8 hrs. Non-lipid plaque stability, reduce cv events, increase bone formation. Liver makes less cholesterol and responds by making more ldl receptors to remove cholesterol from blood. 1 & 2 prevention of cv events. Assess more muscle tenderness, pain, numbness, tingling. Reduces ldl and tg levels, raises hdl (best) Aes: intense flushing, gi upset, liver injury. Hyperglycemia, gouty arthritis, elevated blood uric acid.
