NUR 4227 Lecture Notes - Lecture 4: Bacteriuria, Pyuria, Blood Culture
Document Summary
Immunologic disorder of the kidneys: largely affecting the renal glomerulus, but tubular, interstitial and vascular changes occur, 3rd leading cause of renal failure in us, classifications describe, extent of damage (diffuse/focal, extent of changes (minimal or widespread) Immunoglobulins igg and igm responsible for fixing complement: results in the release of chemotactic factors that attract polymorphonuclear leukocytes, histamine and other inflammatory mediators, end result is glomerular injury. Infections: poststreptococcal gn, 1-2 wk. after strep throat infection (rare skin infection, antibodies to strep antigen develop and deposit in glomeruli (inflammation) Infective endocarditis: heart valve infection, viral infection, can trigger gn, common: hiv, hep b and c. Immune diseases: sle, autoimmune affects joints, skin, kidneys, connective tissue, vascular lesions causing fibrosis, scleroderma. Intermittent or postural proteinuria has been noted in a few clients for as long as 1-2 years after onset: microscopic hematuria usually disappears after 6 months; but as long as 1 year is not uncommon.
