PCB 3233 Lecture Notes - Lecture 3: Immunoglobulin Class Switching, Antigen-Presenting Cell, Rna Splicing
2 Apr 2020
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Somatic recombination occurs in the thymus: rag1 and 2, tdt. They are never secreted therefore do not need to increase affinity. Major difference between b-cells and t-cells is mhc and peptide recognition. There is no somatic hypermutation, rna splicing, or isotype switching for t-cells. Tcr is only an antigen receptor they do not have effector function. Is found on chromosome 14 and is similar to the light chain, vj gene segment. Is found on chromosome 7 and is similar to the heavy chain, vdj gene segment. The c region is simplistic compared to b-cells. Two c (no functional distinction between the two: 4 total attempts. T-cells play a diverse role with other cells. Compared to b and t cells there is not much diversity. However, not everyone"s mch is the same, there is a high degree of diversity within a population (gradient of immune response) Taylers: this prevents total wipe out of a population by 1 pathogen.
