BMD RES 5HA Lecture Notes - Lecture 5: Eosin, Sarcolemma, Sarcoglycan
26 Jan 2017
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Is there an alternative, unmutated protein that can be used to compensate for the loss of dystrophin: dystrophin is too large, hard to inject viruses, etc, think of most logical solution; when it doesn"t work, find alternative ways. If sarcospan is a glue that can stick together to the. Interact with the enzymes that attach the sugars to dystroglycan. It might function like a chaperone in the er/golgi: chaperone: proteins that help other proteins fold correctly or go to the right place. It activates akt signaling to facilitate muscle regeneration. In dr. gibb"s case, she is focusing on the role that sarcospan might have as a dgc scaffold. How to study muscle integrity: assessment of the physical changes in muscle tissue, are the muscles that make more sarcospan more healthy looking, histology of skeletal muscle, h&e staining for general histology.
