BMD RES 5HA Lecture Notes - Lecture 1: Cell Cycle, Dna Replication, Mitosis
17 Apr 2018
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Document Summary
Pre-mrna splicing is a critical step of gene expression. They want to understanding splicing to the highest in order to hopefully prevent and possibly control diseases. Dna is necessary for the rna, codon codes for speci c amino acids. Maturation ( capping and placing a poly-a tail) Editing (rna chang their code after they have been transcribed. Rna interference: destroy rna is no longer needed. Post translational modi cations (physically changed after they"ve been made) Dr. johnson wants to understand how the cells know when to use splicing and how to use it. Three points where the spliceosome has to identify on the intron. 5" boundary site (covalently linked to the branch point to create a lariat strcture) Branch point (somewhere in the middle of the intron) Splice sites between yeast and humans cells have been conserved. Landscape of the eukaryotic genome reveals that splcing is important. Introns make up more of the gene sequence than the exons.
