MCD BIO 165A Lecture Notes - Lecture 10: Protein Disulfide-Isomerase, Endomembrane System, Protein Folding
15 Dec 2016
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Compartments that are continuous w/ ec environment. Lysosomes - digestion of material thru acid hydrolyses (ph =4) Where proteins destined for secretion are made (usually in rough er) Vesicles travel thru diff compartments of the cell. Will (dif)fuse w/ the compartment they are supposed to fuse w/ Select track that will lead them to apical/lateral/basal side. Have proteins that allow bending of lipids: rough = flat cisternae (sac that are flat) Abundance of one depends on the cell type: production of steroid hormone - more ser. Pancreatic cell secrete enzymes: more rer. Ribosomes are actively engaged, always connected to mrna , always producing protein. Ribosomes only come to rer surface when they are bound to mrna. Resident er proteins - live/stay inside lumin of er. Chaperons (i. e. protein disulfide isomerase) for protein folding: use these to visualize where the rer is in cell. Host and help fold proteins that are going to be translated by membrane bound ribosomes: translation location.
