MCD BIO 165A Lecture Notes - Lecture 2: Membrane Lipids, Endocytosis, Glycolipid

• School: UCLA
• Department: Molecular, Cell, and Developmental Biology
• Course: MCD BIO 165A
• Professor: arispe

Document Summary

E. g. people put fibroblast (typical cells of connective tissues) in vitro; (cid:862)ho(cid:449) lo(cid:374)g does it take to (cid:396)e(cid:374)e(cid:449) the e(cid:374)ti(cid:396)e (cid:272)ell (cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)e? (cid:863) Average time for complete renewal of cell membrane: 90 min. High level of interaction between inside & outside membrane. Membrane needs to endocytose; new membrane fusing to cell surface to provide. Renewal in tune with physical feature present & chemical signals. E. g. cold -> e(cid:374)su(cid:396)e (cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)e does(cid:374)"t freeze by increasing unsaturation of fatty acid chains of phospholipids, also change types of lipids. Rea(cid:272)ts to (cid:272)ou(cid:374)te(cid:396)(cid:271)ala(cid:374)(cid:272)e (cid:449)hat it"s se(cid:374)si(cid:374)g -> homeostasis (certain level of normalcy: 2 layers of phospholipids. Proteins embedded in it; some expand thru, other in inner/outer layer. Freedom of movement in sea of lipids