MCD BIO 165A Lecture 18: lecture 18 nucleus
10 Jan 2019
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Lecture 18 nucleus: chromosome location not random, chromosome rearrange and are dynamic structure, envelope: limit of the nucleus; separates nucleus from cytosol translation can occur on nuclear envelope continuation with er, and is the cisternae from er. Has elaborate nucleus skeleton (mostly intermediate filaments (mostly lamins providing shape)) If expose nucleus to detergent, nucleus still keeps the shape -> not nuclear membrane keeping the shape, nucleus skeleton keeps the shape! Nuclear envelope: double membrane, blue balls: ribosomes on rough er, translating (secreted or er resident proteins) Proteins in nucleus made in cytosol & imported into nucleus. Anything made in er contains peptidase signal sequence; 90% of those are either transmembrane proteins or secreted. Proteins remaining in cell made in cytosol transmembrane proteins critical in communication between nucleus & rest of cell. Nesprin family proteins bridge cytoplasm (if?) with nucleus transmembrane proteins. Continuum of information transmitted by individual proteins from outside into nucleus.
