MCD BIO 90 Lecture 5: Cell Programming
5 Apr 2018
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This involves manipulating the gene expression of a adult fully-differentiated cell and turning it into a pluripotent cell. The easiest adult cell to use is the skin cell, as it is the least invasive procedure. From skin cell to pluripotent stem cell to neuron. Methods 1 to 6, all of which are inducing pluripotent cells (ipscs) Process by which an unfertilized oocyte becomes activated and begins to divide. Mimics the calcium-dependent processes of post-fertilization using specific factors to take oocyte out of mii arrest. Because the hardening of the zona pellucida begins the process of fertilization (after the sperm cell releases certain chemicals), by releasing the chemicals, we could recreate the hardening and enable this process. The egg will begin dividing, but due to the lack of half of the genetic material, they are limited in their use. It gives us a half haploid population of embryonic cells.
