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Lecture 1

MCD BIO 90 Lecture Notes - Lecture 1: Viral Vector, Myc, Oncogene


Department
Molecular, Cell, and Developmental Biology
Course Code
MCD BIO 90
Professor
Mitra Hooshmand
Lecture
1

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Thursday, October 10, 2019
MCDB 90
Discussion 2!
-Similarities!
Look the same, potency, colony, functions, result of manipulation!
-Dierences!
ESCs!
-Source is limited, from the blastocyst, ICM!
-Younger, no epigenetic memory!
-Controversy, ethical concerns!
-Less risky!
iPSCs!
-Personalized — reduce the chance of rejection!
-Epigenetic memory — reprogramming is imperfect and inecient, the cells
are more likely to reverse to the previous cell !
-Any adult cells !
-c-Myc is related to cancer —oncogenes — you have to make sure that is
shut o and suppressed after!
-Viral vectors — break the genome — introduce proteins, or not permanently
changing the genome
1
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