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Lecture 19

MCD BIO 90 Lecture Notes - Lecture 19: Diabetes Mellitus Type 1, Cord Blood, Dementia


Department
Molecular, Cell, and Developmental Biology
Course Code
MCD BIO 90
Professor
Mitra Hooshmand
Lecture
19

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2 December 2019
FDA authorized clinical trials
IND number: investigational new drug number ! FDA starts to go through the package
Google the IND number. Cber.com
Bigger problem:
Average cost of these treatment
More than $700 a treatment for platelets
Up to $5,000 for fat and bone marrow injections (not necessarily invasive operation
still cost high)
Can cost up to $100,000 (BBC News anchorwoman spent $84,000)
Insurance does not cover these procedures. No clinical trials for cell-based therapy or
stem cell treatment are FDA approved except for blood-forming stem cells
(hematopoietic progenitor cells) derived from cord blood.
Isscr.com dedicated to protecting patients. Check whether the clinic is fake or not
Basic stuff to think about
1. Currently, very few stem cell treatments have been proven safe and effective
2. There is something to lose when you try an unproven treatment
e.g. injected cells die, mount immune response, you might die from that
Complications create new short- and long-term health problem
Receipt of one unproven or experimental treatment may make you ineligible for
future clinical trials or treatment options
Out-of-pocket expenses could be enormous
If travel is involved, there are additional considerations
3. Different types of stem cells serve different purposes in the body
4. The same stem cell treatment is unlikely to work for different diseases or
conditions (if the fake clinic claims to be able to treat many diseases with the
same stem cell)
5. Science behind a disease should match the science behind the treatment. (e.g.
type I diabetes is an autoimmune diseases. So ask about how the stem cell help
with immune system, cuz they would be killed anyway) so it is important to
understand the mechanism of the disease
6. Cells from your own body are not automatically safe when used in treatments
Autologous ! not necessarily safe
Might change the property of the cells, then will mount immune response
Any time cells are removed from your body, there is a risk they may be contaminated
with viruses, bacteria or other pathogens that could cause disease when reintroduced
Manipulation of cells by a clinic may interfere with their normal function, including
those that control cell growth
How and where the cells are put back into your body matters. Some clinics inject
cells into places where they are not normally present and do not belong
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