MCD BIO C141 Lecture Notes - Lecture 10: Leucine Zipper, Dna-Binding Domain, Zipper
15 May 2020
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Recall the connection and regulation between hd-zip iiis and little zippers. Give examples of how abaxial specifiers differ from adaxial specifiers. Enhancer screen: transcriptional regulation: post-transcriptional regulation: post-translational regulation. Function unclear all dominant mutations found in start domain-none are stops, all mis-sense. Hd-zip iii"s are regulated by a family of micrornas (mir 165/166) Dominant mutations in mir binding site cause improper accumulation of hd-zip iii mrna. Leads to leaf adaxialization-loss of both medial lateral and proximal distal outgrowth. Phab is being misexpressed and resitent to mirna. In many plant species there has been gene duplication, sometimes multiple rounds (can cause a stop codon but would still cause gene duplication) Examples such as kn1 in maize and ham genes in arabidopsis illustrate this. Many plant genes and pathways have been uncovered through the identification of semi-dominant or dominant alleles, but these are rare.
