MIMG 101 Lecture Notes - Lecture 1: Salmonellosis, Adaptive Immune System, Phagosome

• School: UCLA
• Department: Microbiology, Immunology, and Molecular Genetics
• Course: MIMG 101
• Professor: G U N S A L U S& B R A D L E Y

Document Summary

Infection of a host by a pathogen elicits changes in both the pathogen and the host: changes in the pathogen: activation of systems to ensure infection elude or neutralize host defenses. The goals are: to obtain nutrients, avoid host defenses, and transmit to new hosts (killing your host is often a bad idea!) **intracellular pathogens can be a) obligate - restricted to intracellular survival. Protozoa: toxoplasma gondii, plasmodium spp: facultative - both intracellular and extracellular survival. Microbes can gain access to host cells by several pathways: phagocytosis: involves the extension of pseudopodia around a particle and its ingestion into a tight vesicle. _common mechanism of entry by a number of pathogens also the mechanism by which the human cell eliminates potentially harmful organisms occurs by a zippering mechanism into a membrane-bound vacuole (this is how human microphage ingests. Mechanisms: a macrophage engulfs the invading bacterium inside pseudopodium. Membrane fusion occurs to form the primary phagosome.