MIMG 102 Lecture Notes - Lecture 17: Titer, Humoral Immunity, Interferon

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Interferon: groups of proteins protecting host from viral infection. Small & stable; can"t be destroyed by acid. Stops viral replication: specifically targets viruses (not bacteria!!) and all viruses (no specific group, e. g. of interferon induced enzymes: rpk phosphorylating eif2. Interferon establishes anti-viral stage in uninfected cells around infected cell. Infected cell knows imma die -> signals to uninfected neighbor cells & sends out interferon -> binds receptor on neighbors -> signals to nucleus, makes proteins -> anti-viral stage in neighboring cells. If first-line interferon defense fails: humoral immunity & cell-mediated immunity. Humoral immunity: b cells antibodies which neutralize virus. Cell-mediated immunity: t cells recognize & ill infected cells. In patients: influenza virus titer peaks after 5-6 days. But anti-influenza antibodies not correlating with flu titer (peaks way later) So antibodies not responsible for lowering virus titer (because made much later) Infect egg with influenza -- 2 days later --> remove chorioallontoic fluid -> into container, lower ph to 2.

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