MCD BIO 138 Lecture Notes - Lecture 7: Cell Adhesion, Feedback, Morphogen

• School: UCLA
• Department: Molecular, Cell, and Developmental Biology
• Course: MCD BIO 138
• Professor: karenlyons

Document Summary

Mutation will make all cell think it is anterior. Missing/abnormal large domains --> higher up the hierarchy. Pair rule genes: delete part of every pair of segments (inidv segments abnormal) Segment polarity genes: delete part of every segment (parts of segments. Segment polarity genes: delete part of every segment (parts of segments abnormal) Mutations will lack portion of the a/p axis. Either expressed in even numbered or odd numbered parasegments. Expression in each stripe is independently controlled by maternal and gap (tf) genes and different enhancers in each stripe. Lose of a pair rule gene results in defect in every other segment as a result. Expressed in just one stripe/a portion of each segment. Pair rule genes initially turn segmentation genes on but then will regulate themselves using feedback loop. Destroying the loop causes loss of a/p identity. Are expressed on either side of the parasegment boundaries. Feedback loop across adj parasegments maintains expression of each +