NEUROSC 10 Lecture Notes - Lecture 9: Microelectrode, Alan Lloyd Hodgkin, Saltatory Conduction
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It measures the direction of flow for a positive ion. Ion transporters: actively move ions against concentration gradient, create ion concentration gradients. K+ (potassium) ions to the inside: a lot of sodium ions on the outside, less (but mostly) potassium ions on the inside. Ca2+-activated k+, cyclic nucleotide gated channel: membrane potential, caused by difference in charge across the cell membrane, membrane potential is measured in mv relative to the outside of the cell. Inside - outside: resting net charge difference is negative for neurons, so membrane potential is negative (-70 mv, resting means there is little activity going on in the neuron and. leak channels provide most of the cell membrane"s permeability to ion flow: the net flow of ions is zero. Ion flow at rest: differences in ion concentration between the inside and outside, diffusion, differences in permeability of membrane to ions.