NEUROSC M101C Lecture Notes - Lecture 5: Amygdala, Dopamine Receptor D1, Adipocyte
Document Summary
We have particular brain regions important for reward liking (e. g. vp, nac shell and mor) No in uence on measures of reward wanting when manipulating circuits implicated in pleasure/hedonic impact. Conversely, manipulating other areas/circuits are important for reward wanting/reward predictive cues doesn"t in uence measures of reward liking. Wanting and liking brain mechanisms are dissociable, implying these are dissociable sociological and psychological processes. In ating wanting over liking can produce maladaptive behaviors. Under normal circumstances, food stimuli should elicit less attention. Cs+ invigorates lever presses more robustly when hungry than when sated. 18 hrs vs 1 hr of food deprivation. Food cues robustly elevate da release in nac core. In sated state (recently fed), cues are much less capable of releasing dopamine. Dopamine-mediated motivational impact is dampened when sated. Another homeostatic start signal that increase food-motivated behavior. May be interacting with wanting circuit in brain, depending on activity. Bath apply orexin a and orexin b.
