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Class Notes for PHYSCI 121 at University of California - Los Angeles (UCLA)

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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 31: Glycan, Golgi Apparatus, Lipid Bilayer

OC12750214 Page
8 Mar 2020
0
Glycans are abundant on the surface of cells. Although this specific example is one of a fibroblast cell, the muscle cell would be no different. The li
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 30: Deflazacort, Prednisone, 10-Meter Band

OC12750213 Page
8 Mar 2020
0
Physical therapies and outcomes for dmd patients part 3. Natural history studies: how does a measurement change over time, outcome measurements are cri
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 21: Cd133, Myocyte, Blood Vessel

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19 Feb 2020
0
Stem cells: properties, sources & relevance to dmd. What is a stem cell? a cell that can replicate itself through self-renewal. Stem cells are the only
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 24: Flow Cytometry, Micrograph, Lesion

OC12750213 Page
19 Feb 2020
0
Even in areas with healthy looking muscle fibers. Not contractile tissue and inhibits the range of motions, the muscle begins to shorten in dmd patient
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 23: Monocyte, Muscle Tissue, Blood Vessel

OC12750213 Page
19 Feb 2020
0
Immune cells enter the muscle when damaged and envelope the muscle fibers. And what happens in the presence or absence of these cells. Removing the mon
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 15: Neuromuscular Junction, Dystrophin, Antibody

OC12750212 Page
10 Feb 2020
0
What is utrophin: discovered in 1989, protein encoded by the utrn gene. Expresses dystrophin paralog: chromosome 6q24 (human, 13 kb transcript 395kda s
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 11: Exon Skipping, Drisapersen, Eteplirsen

OC12750215 Page
27 Jan 2020
0
Many boys can be treated with the same exon skipping procedure. Exon skipping can occur in other exons, and these procedures can impact 80% of boys. Ex
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 5: Polyacrylamide Gel Electrophoresis, Digitonin, Dystrophin

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20 Jan 2020
0
Duchenne muscular dystrophy (dmd) is caused by a defective gene found on the x-chromosome. Dystrophin is encoded by the dmd gene and represents about 0
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 19: Nitric Oxide Synthase, Cgmp-Specific Phosphodiesterase Type 5, Nos1

OC12750213 Page
11 Feb 2020
0
No-cgmp pathway as a new drug target for muscular dystrophy. Pde5 inhibitors (or no donors) improve muscle blood flow in bmd and dmd. Will better blood
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 17: Scientific Method, Health Insurance Portability And Accountability Act, Quality Assurance

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10 Feb 2020
0
Research is important because it improves conditions and provides more info to make better medication: research is a systematic investigation designed
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture 13: Physci week 4 lect 5

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30 Jan 2020
0
Episomal vectors can be rapidly lost from cells. System can go in and bind to specific sequences of the gene to fix mutations: adapted from natural sys
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UCLAPHYSCI 121CrosbeWinter

PHYSCI 121 Lecture Notes - Lecture 6: Cell Culture, Fibroblast, Jackson Laboratory

OC12750215 Page
22 Jan 2020
0
Benefit: grow under controlled conditions, outside of natural environment. Lacks immune system response: does not replicate disease process. One with h
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