PHYSCI 121 Lecture Notes - Lecture 21: Cd133, Myocyte, Blood Vessel
Document Summary
Stem cells: properties, sources & relevance to dmd. What is a stem cell? a cell that can replicate itself through self-renewal. Stem cells are the only ones that can do this. It can also make functional cell type (carries out the important functions of the cell: neurons, muscle cells, etc. ) Embryonic cell types can differentiate into any lineage while adult cells are limited. Satellite (muscle: myoblast (muscle, mesangioblast (blood vessels, mesenchymal (stromal, bone marrow, fat, etc. , cd133 positive (blood or muscle, pericytes (blood vessel or muscle, muscle derived (muscle) Located between the sarcolemma and the extracellular matrix of muscle. Following injury, satellite cells divide and give rise to myoblasts. Once they get the signals, they get a quiescence to make more stem cells. These are closely talking to other signals in the muscular cells. There are other cell surface markers specific to the cell that can be good for clinical trials.
